Lionel Messi was pulled in the first half against defending champion Lille.
The Argentine began to attack with Paris Saint-Germain in the absence of Kylian Mbappe.
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But he failed to make any impact as he roamed the field at the Parc des Princes.
Poor performance can be linked to a muscle injury he sustained earlier this week.
Messi missed PSG training yesterday, but declared he is fit enough to start.
He was suspended at halftime after failing to muster the shockwave on goal and was replaced by compatriot Mauro Icardi, who is back after a public feud with his wife Wanda.
The Argentine has not yet scored in the league for the Parisians.
After five Ligue 1 matches, the 34-year-old has made an appearance No goals or helps to demonstrate it.
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However, he has three goals in the Champions League group stage.
Lille took the lead shortly after the half-hour mark, with Canadian Jonathan David leading the net into the near post.
This came after some great play started by Renato Sanchez.
The ball was passed superbly across the PSG penalty area and in the direction of David, who put the finishing touch.
It took 40 minutes for PSG to find a response.
Captain Marquinhos came to the host side, positioning himself well at the far post.
The Brazilian modified his body and shot high into the net to finish off the runway.
Two minutes before the end of the match, it was Di Maria who scored all the important goals.
The Argentine played a double match with Neymar before hitting a low shot in the lower right corner.
The win expands Paris Saint-Germain’s lead at the top of the French league to 29 points, eight points ahead of Lens, who plays with Lyon tomorrow.
Lille finds themselves in the middle of the group in tenth place, 14 points behind the league leaders, and it seems unlikely that they will retain their title.
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